Although IOTA-5563 is classified as a general chemical (non-flammable, non-explosive) and can be transported by conventional land, sea, or rail, its hydrolytic sensitivity and potential irritant properties should still be considered during handling.

Storage Recommendations:
- Store in a dry, cool, and well-ventilated indoor environment at a temperature recommended to be controlled between 5–30°C;
- Strictly avoid contact with water, acids, and alkalis, as its methoxy group readily hydrolyzes to form methanol and silanols, leading to product degradation;
- Packaging is typically 25 kg paper drums lined with polyethylene bags. Once opened, use as soon as possible or seal and store under nitrogen.

Handling Safety:
- Although there are no reports of high toxicity, it is recommended to wear protective gloves, goggles, and a mask to prevent the accumulation of organic vapors;
- If contact with skin or eyes occurs, immediately flush with plenty of water;
- The work area should be equipped with ventilation equipment to prevent vapor buildup (although the flash point is high at 105°C, fire prevention is still necessary).

Waste Disposal:
- Waste liquid must not be directly discharged into sewers; it should be disposed of by a professional organization in accordance with local hazardous waste regulations.
- Container cleaning water must also be collected and treated to avoid environmental pollution.

Proper use of IOTA-5563 not only maximizes its excellent coupling effect but also ensures production safety and environmental compliance.