While octyltrimethoxysilane (CAS 3069-40-7) has a wide range of applications, safe handling is paramount. It is a flammable liquid (flash point approximately 85°C), and its vapors can ignite upon contact with open flames or high temperatures. Direct contact with skin or eyes can cause irritation and swelling, and prolonged inhalation of low concentrations of vapors may lead to headaches or respiratory discomfort. Even more concerning is its hydrolysis product, methanol—a toxic and volatile substance. Handling with methanol must be conducted in a fume hood, equipped with a respirator, chemically resistant gloves (such as nitrile rubber), and safety goggles. During storage, it should be kept in a cool, dry place, away from water sources and oxidizers. Containers must be sealed and labeled with a "flammable" warning. Environmentally, this compound can slowly biodegrade in the environment, but the methanol released during hydrolysis can harm aquatic life if it enters water bodies. Therefore, industrial wastewater must undergo professional treatment: first neutralization and hydrolysis, followed by purification through activated carbon adsorption or biodegradation processes; direct discharge is strictly prohibited. Global regulations such as the EU's REACH and China's Regulations on the Administration of Hazardous Chemicals strictly govern its use, requiring companies to conduct risk assessments and provide Safety Data Sheets (SDS). Individual users (such as DIY enthusiasts) should purchase small packages, operate in open spaces, and dispose of any remaining materials at hazardous waste recycling centers. Encouragingly, the industry is promoting the development of green alternatives, such as aqueous silane systems, to reduce environmental footprint. Remember: safety is paramount, and every proper operation is a sign of respect for life. When used correctly, n-octyltrimethoxysilane can create significant value for society while protecting the ecological balance.