At the forefront of new materials research and development, scientists often use the sol-gel method to synthesize nano-silica, organic-inorganic hybrid materials, or functional coatings under mild conditions. Methyltrimethoxysilane (MTMS) is one of the star precursors in this process.

Traditional tetraethyl orthosilicate (TEOS) hydrolyzes to form a pure inorganic silica network, which is brittle and hard. However, by introducing methyltrimethoxysilane, organic methyl groups are embedded in the network formed by hydrolysis and condensation, resulting in organically modified silica (ORMOSIL). These materials combine the thermal stability of inorganic materials with the flexibility of organic materials, and can be used to fabricate transparent films, low-dielectric-constant coatings, anti-fog lenses, and even biosensor carriers.

For example, co-hydrolyzing MTMS with TEOS can prepare a hydrophobic coating with a microporous structure, which can be used on the surface of solar panels, providing dust and water resistance without affecting light transmittance. In the laboratory, MTMS can also be used to modify the surface of magnetic nanoparticles, improving their dispersibility in organic solvents and facilitating subsequent functionalization. Due to its controllable reaction, uniform film formation, and moderate cost, methyltrimethoxysilane has become an important "molecular glue" connecting macroscopic materials and the nano world.